Spreading Depression and Neurovascular Coupling

Spreading depression and neurovascular coupling.

Focussed Research Group Cerebral Blood Flow, Neurovascular Coupling, and Cortical Spreading Depression Organizers:

Due to the complexity of the multiple topics discussed at this workshop, the group of participants possess diverse and complementary expertise. Here is a brief description of the participants. K.C. Brennan (Utah, Neuroscience) Brennan is a neurologist with interests in headache. His research explores the effects of CSD on blood vessels and vice versa. J.C. Chang (Ohio State, Math. Biosciences I...

Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling

Aneurysmal subarachnoid hemorrhage (SAH) has devastating consequences on brain function including profound effects on communication between neurons and the vasculature leading to cerebral ischemia. Physiologically, neurovascular coupling represents a focal increase in cerebral blood flow to meet increased metabolic demand of neurons within active regions of the brain. Neurovascular coupling is ...

The Bimodal Nature of Neurovascular Coupling

Neurons, by virtue of their complex and continuously changing signaling roles in brain, must be able to regulate access to energy in order to maintain their ability to communicate meaningful frequency-encoded information. This is accomplished by release of neurotransmitters to astrocytes that in turn signal the vascular system to increase cerebral blood flow (CBF). This process has been termed ...

Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling.

Cortical spreading depression (CSD) is a pronounced depolarization of neurons and glia that spreads slowly across the cortex followed by a period of depressed electrophysiological activity. The vascular changes associated with CSD are a large transient increase in blood flow followed by a prolonged decrease lasting greater than 1 h. Currently, the profile of functional vascular activity during ...